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Decreased plasma cysteinylglycine and taurine levels in branch retinal vein occlusion

Pinna, Antonio <1963- > and Zinellu, Angelo and Franconi, Flavia and Solinas, Maria Giuliana and Carru, Ciriaco (2010) Decreased plasma cysteinylglycine and taurine levels in branch retinal vein occlusion. Ophthalmic Research, Vol. 43 (1), p. 26-32. eISSN 1423-0259. Article.

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DOI: 10.1159/000246575

Abstract

Purpose: Our aim was to determine the plasma levels of the sulfur-containing amino acids homocysteine, cysteine, cysteinylglycine, glutamylcysteine, glutathione and taurine in patients with branch retinal vein occlusion (BRVO) and in healthy subjects and to ascertain whether there are statistically significant differences between patients and controls. Methods: Homocysteine, cysteine, cysteinylglycine, glutamylcysteine, glutathione and taurine plasma levels were measured in 40 patients with BRVO and 80 age- and gender-matched control subjects by using laser-induced fluorescence capillary electrophoresis methods. Wilcoxon's or Student's t test was used, when appropriate, to determine differences between the groups. Conditional logistic regression analysis was performed to determine the risk factors for BRVO. Results: BRVO patients showed significantly lower plasma concentrations of cysteinylglycine (p = 0.02) and taurine (p < 0.0001) than controls. Conversely, there were no significant differences in plasma homocysteine, cysteine, glutamylcysteine and glutathione between patients with BRVO and controls. Conditional logistic regression analysis revealed an odds ratio of 0.95 (95% confidence interval: 0.92-0.98, p = 0.001) for taurine and 0.86 (95% confidence interval: 0.78-0.96, p = 0.006) for cysteinylglycine. Conclusions: This study failed to demonstrate an association between BRVO and the plasma levels of homocysteine, cysteine, glutamylcysteine and glutathione. Cysteinylglycine and taurine were significantly lower in BRVO patients, thus suggesting that reduced plasma levels of these sulfur-containing amino acids may contribute to the pathogenesis of BRVO.

Item Type:Article
ID Code:3742
Status:Published
Refereed:Yes
Uncontrolled Keywords:Branch retinal vein occlusion, homocysteine, cysteine, cysteinylglycine, glutamylcysteine, glutathione, taurine, laser-induced fluorescence capillary electrophoresis
Subjects:Area 06 - Scienze mediche > MED/42 Igiene generale e applicata
Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 02 Centri > Centro di eccellenza interdisc. sviluppo ricerca biotecnologica e studio biodiversità della Sardegna e dell'area mediterranea
001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
001 Università di Sassari > 03 Istituti > Igiene e medicina preventiva
Publisher:Karger
eISSN:1423-0259
Deposited On:16 Apr 2010 16:02

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