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Bis- and tris(pyridyl)amine-oxidovanadium complexes: characteristics and insulin-mimetic potential

Nilsson, Jessica and Degerman, Eva and Haukka, Matti and Lisensky, George C. and Garribba, Eugenio and Yoshikawa, Yutaka and Sakurai, Hiromu and Enyedy, Éva A. and Kiss, Tamás and Esbak, Hossein and Rehder, Dieter and Nordlander, Ebbe (2009) Bis- and tris(pyridyl)amine-oxidovanadium complexes: characteristics and insulin-mimetic potential. Dalton Transactions, Vol. 2009 (38), p. 7902-7911. eISSN 1477-9234. Article.

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DOI: 10.1039/b903456k


Two novel vanadium complexes, [VIVO(bp-O)(HSO4)] (1) and [VIVO(bp-OH)Cl2]•CH3OH (2•CH3OH), where bp-OH is 2-{[bis(pyrid-2-yl)methyl]amine}methylphenol, were prepared and structurally characterised. EPR spectra of methanol solutions of 2 suggest exchange of Cl- for CH3OH and partial conversion to [VO(bp-OH)(CH3OH)3]2+. Speciation studies on the VO2+-bpOH system in a water/dmso mixture (4:1 v/v) revealed [VO(bp-O)(H2O)n]+ as the dominating species in the pH range 2–7. The insulin-mimetic properties of 1 and 2, [VIVO(SO4)tpa] (3), [VIVO(pic-trpMe)2] (5) and the new mixed-ligand complexes [VVO(pic-trpH)tpa]Cl2 (4Cl2) and [VVO(pic-OEt)tpa]Cl2 (6Cl2), tpa = tris(pyrid-2-yl)methylamine, picH-trpH = 2-carboxypyridine-5-(L-tryptophan)carboxamide (picH-trpMe is the respective tryptophanmethyl ester), pic-OEt = 5-carboethoxypyridine-2-carboxylic acid, were evaluated with rat adipocytes, employing two lipolysis assays (release of glycerol and free fatty acids (FFA)), respectively and a lipogenesis assay (incorporation of glucose into lipids). The IC50 values for the inhibition of lipolysis in the FFA assay vary between 0.41 (±0.03) (5) and 21.2 (±0.6) mM (2), as compared to 0.81 (±0.2) mM for VOSO4.

Item Type:Article
ID Code:3735
Uncontrolled Keywords:Vanadium complexes, insulin-mimetic potential
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:Royal Society of Chemistry
Deposited On:15 Apr 2010 13:21

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