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Outcome of acute monosymptomatic optic neuritis in Northern Sardinia, Italy

Pinna, Antonio <1963- > and Dessole, Laura and Pugliatti, Maura and Sotgiu, Stefano and Solinas, Maria Giuliana and Carta, Arturo (2007) Outcome of acute monosymptomatic optic neuritis in Northern Sardinia, Italy. Neuro-Ophthalmology, Vol. 31 (3), p. 69-72. eISSN 1744-506X. Article.

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DOI: 10.1080/01658100701407760

Abstract

Purpose: To define the outcome of acute monosymptomatic optic neuritis (AMON) in Northern Sardinia, Italy. Methods: Records of all AMON patients admitted at the Institute of Ophthalmology, University of Sassari, between 1991 and 2002 were reviewed. The Kaplan-Meier method was used to calculate the cumulative probability of remaining free from clinically definite multiple sclerosis (CDMS). Results: 22 patients (16 women, 6 men) met the inclusion criteria. Mean age at onset was 29.4 years. Mean age-adjusted incidence was 0.91 per 100,000 population per year. Best-corrected visual acuity (BCVA) at presentation was < 20/200 in 12 (54.5%) patients. Brain MRI revealed evidence of two or more demyelinating lesions in all patients. Five (22.7%) eyes had final BCVA < 20/200. Fifteen (68.2%) patients developed CDMS within 7 years. The cumulative probability of remaining free from CDMS was 45% after 36 months and 26% after 82 months. Conclusions: Results suggest that Sardinian patients with AMON may have a worse visual prognosis and a higher risk of developing CDMS.

Item Type:Article
ID Code:3727
Status:Published
Refereed:Yes
Uncontrolled Keywords:Acute monosymptomatic optic neuritis, brain MRI lesions, multiple sclerosis, visual outcome
Subjects:Area 06 - Scienze mediche > MED/42 Igiene generale e applicata
Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
001 Università di Sassari > 03 Istituti > Clinica neurologica
001 Università di Sassari > 03 Istituti > Igiene e medicina preventiva
Publisher:Informa Healthcare
eISSN:1744-506X
Deposited On:14 Apr 2010 11:04

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