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Increased plasma asymmetric dimethylarginine (ADMA) levels in retinal venous occlusive disease

Zinellu, Angelo and Pinna, Antonio <1963- > and Sotgia, Salvatore and Zinellu, Elisabetta and Usai, Maria Franca and Carta, Francesco and Gaspa, Leonardo and Deiana, Luca and Carru, Ciriaco (2008) Increased plasma asymmetric dimethylarginine (ADMA) levels in retinal venous occlusive disease. Clinical Chemical Laboratory Medicine, Vol. 46 (3), p. 387-392. eISSN 1437-4331. Article.

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DOI: 10.1515/CCLM.2008.063

Abstract

Background: We investigated the levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA), as well as homocysteine and cysteine thiols, in a cohort of subjects affected by retinal vein occlusion (RVO) disease.
Methods: Capillary electrophoresis analysis was performed in both RVO subjects (n=54) and in a control group (n=32).
Results: No differences were found between controls and patients; however, after categorisation for RVO type, central RVO (CRVO) patients showed higher levels of ADMA (0.710±0.139 μmol/L) than controls (0.635±0.117 μmol/L) and branch RVO patients (0.642±0.096 μmol/L). Moreover, cysteine plasma levels were also significantly higher in CRVO patients than in controls (265.8±46.9 vs. 226.7±51.9 μmol/L, p<0.01), while homocysteine plasma concentration was more or less identical in all groups.
Conclusions: We hypothesise that the elevated levels of cysteine in CRVO patients may post-translationally inhibit dimethylarginine dimethylaminohydrolase enzyme activity, as already described for homocysteine, thus contributing to the accumulation of ADMA in this patient group.

Item Type:Article
ID Code:3706
Status:Published
Refereed:Yes
Uncontrolled Keywords:Asymmetric dimethylarginine (ADMA), dimethylarginine dimethylaminohydrolase (DDAH) inhibition, retinal vein occlusion, symmetric dimethylarginine (SDMA)
Subjects:Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
002 Altri enti e centri di ricerca del Nord Sardegna > National laboratory of the national institute of biostructures and biosystems, Osilo
Publisher:de Gruyter
eISSN:1437-4331
Deposited On:09 Apr 2010 15:38

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