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Glucose-6-phosphate dehydrogenase deficiency in retinal vein occlusion

Pinna, Antonio <1963- > and Carru, Ciriaco and Solinas, Maria Giuliana and Zinellu, Angelo and Carta, Francesco (2007) Glucose-6-phosphate dehydrogenase deficiency in retinal vein occlusion. Investigative Ophthalmology and Visual Science, Vol. 48 (6), p. 2747-2752. eISSN 1552-5783. Article.

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DOI: 10.1167/iovs.06-1064

Abstract

PURPOSE. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, with a high prevalence in Sardinia, Italy. Evidence indicates that G6PD-deficient patients are protected against ischemic heart and cerebrovascular disease. The purpose of this study was to assess the frequency of G6PD deficiency in Sardinian patients with retinal vein occlusion (RVO) and to ascertain whether the deficiency may offer protection against RVO.
METHODS. Erythrocyte G6PD levels were measured in 448 consecutive RVO patients: 194 with central RVO (CRVO) and 254 with branch RVO (BRVO). Age- and sex-matched subjects (n = 896) who were undergoing cataract surgery and had no history of RVO served as the control. Multiple logistic regression models were used to investigate the association between G6PD deficiency and RVO, CRVO, or BRVO.
RESULTS. G6PD deficiency was found in 21 (4.7%) patients with RVO, 7 (3.6%) with CRVO, 14 (5.5%) with BRVO, and 107 (11.9%) control subjects. Differences between cases and controls were statistically significant (P < 0.005). Multiple conditional logistic regression analysis, including as covariates G6PD deficiency, hypertension, diabetes, and hypercholesterolemia, revealed that G6PD deficiency was significantly associated with decreased risk of development of RVO, CRVO, or BRVO. After adjustment for hypertension, diabetes, and hypercholesterolemia, the association between G6PD deficiency and RVO, CRVO, or BRVO remained statistically significant. Similar results were obtained after adjustment for systolic or diastolic blood pressure, plasma glucose, and cholesterol levels. However, when the patients with CRVO or BRVO were categorized by gender, a significant association was found only in the women.
CONCLUSIONS. The frequency of G6PD deficiency in patients with RVO was significantly lower than expected. The results suggest that G6PD-deficient patients have a significantly decreased risk of development of RVO in the Sardinian population.

Item Type:Article
ID Code:3703
Status:Published
Refereed:Yes
Uncontrolled Keywords:Glucose-6-phosphate dehydrogenase (G6PD) deficiency, retinal vein occlusion (RVO), logistic regression analysis, Sardinian population
Subjects:Area 06 - Scienze mediche > MED/42 Igiene generale e applicata
Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
001 Università di Sassari > 03 Istituti > Igiene e medicina preventiva
Publisher:Association for Research in Vision and Ophthalmology
eISSN:1552-5783
Deposited On:09 Apr 2010 12:21

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