A Mild and inexpensive procedure for the synthesis of n,n′-di-Boc-protected guanidines

A Mild and inexpensive procedure for the synthesis of n,n′-di-Boc-protected guanidines

Porcheddu, Andrea and De Luca, Lidia Vera Giovanna and Giacomelli, Giampaolo (2009) A Mild and inexpensive procedure for the synthesis of n,n′-di-Boc-protected guanidines. Synlett, Vol. 2009 (20), p. 3368-3372. eISSN 1437-2096. Article.

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DOI: 10.1055/s-0029-1218365

Abstract

A novel and efficient synthetic procedure for converting a diverse set of amines to N,N′-di-Boc-protected guanidines is described. The methodology comprises the use of cyanuric chloride (TCT) as activating reagent for di-Boc-thiourea. The employ of inexpensive TCT instead of classical HgCl₂ eliminates the environmental hazard of heavy-metal waste without appreciable loss of yield or reactivity. This protocol provides an alternative route for the guanylation of amines from those currently employed.

Item Type:	Article
ID Code:	3668
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Cyanuric chloride, TCT, guanidine, N,N′-di-Boc-protected guanidines, guanylating reagent
Subjects:	Area 03 - Scienze chimiche > CHIM/06 Chimica organica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:	Thieme
eISSN:	1437-2096
Deposited On:	31 Mar 2010 13:46

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