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A Straightforward route to Piloty's acid derivatives: a class of potential nitroxyl-generating prodrugs

Porcheddu, Andrea and De Luca, Lidia Vera Giovanna and Giacomelli, Giampaolo (2009) A Straightforward route to Piloty's acid derivatives: a class of potential nitroxyl-generating prodrugs. Synlett, Vol. 2009 (13), p. 2149-2153. eISSN 1437-2096. Article.

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DOI: 10.1055/s-0029-1217565

Abstract

A series of Piloty's acid derivatives were easily prepared under mild and neutral conditions. The ease of isolation of the final product offers a marked advantage over well-known procedures. This methodology is particularly attractive as it cleanly provided low molecular weight aliphatic sulfohydroxamic acids, which are very interesting for their tendency to generate HNO under physiological conditions.

Item Type:Article
ID Code:3667
Status:Published
Refereed:Yes
Uncontrolled Keywords:Piloty's acid, NO, HNO, MgO, sulfohydroxamic acids
Subjects:Area 03 - Scienze chimiche > CHIM/06 Chimica organica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:Thieme
eISSN:1437-2096
Deposited On:31 Mar 2010 13:46

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