Porcheddu, Andrea and De Luca, Lidia Vera Giovanna and Giacomelli, Giampaolo (2009) A Straightforward route to Piloty's acid derivatives: a class of potential nitroxyl-generating prodrugs. Synlett, Vol. 2009 (13), p. 2149-2153. eISSN 1437-2096. Article.
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A series of Piloty's acid derivatives were easily prepared under mild and neutral conditions. The ease of isolation of the final product offers a marked advantage over well-known procedures. This methodology is particularly attractive as it cleanly provided low molecular weight aliphatic sulfohydroxamic acids, which are very interesting for their tendency to generate HNO under physiological conditions.
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