De Luca, Lidia Vera Giovanna and Giacomelli, Giampaolo and Nieddu, Giammario (2008) Synthesis of substituted benzofurans via microwave-enhanced catch and release strategy. Journal of Combinatorial Chemistry, Vol. 10 (4), p. 517-520. eISSN 1520-4774. Article.
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A microwave-enhanced procedure for the synthesis of substituted benzofurans starting from 2-(1-hydroxyalkyl)-phenols and using triphenylphosphine polystirene resin is reported. The benzofurans are isolated in good to high yields and purities by simple workup. The procedure can be applied to chiral α-alkyl-2-benzofuranmethanamines too.
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