Porcheddu, Andrea and Giacomelli, Giampaolo and Piredda, Ivana (2009) Parallel synthesis of trisubstituted formamidines: a facile and versatile procedure. Journal of Combinatorial Chemistry, Vol. 11 (1), p. 126-130. eISSN 1520-4774. Article.
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A focused library of formamidines having several diversity points has been prepared. The use of isocyanate resin as scavenger may offer several practical advantages over conventional procedures, such as the ease of workup and availability. The technique described herein was performed in a parallel synthesis format. The whole protocol has potential use in high throughput synthesis for the preparation and purification of libraries of unsymmetrical formamidines containing sets of different aliphatic substituents.
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