UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Synthesis and evaluation of different fatty acid esters formulated into Precirol® ATO-based lipid nanoparticles as vehicles for topical delivery

Sanna, Vanna Annunziata and Mariani, Alberto and Caria, Giuseppe and Sechi, Mario (2009) Synthesis and evaluation of different fatty acid esters formulated into Precirol® ATO-based lipid nanoparticles as vehicles for topical delivery. Chemical and Pharmaceutical Bulletin, Vol. 57 (7), p. 680-684. eISSN 1347-5223. Article.

Full text not available from this repository.

DOI: 10.1248/cpb.57.680

Abstract

A series of isopropyl fatty esters having different chain length (C13—C23) were synthesized and formulated in lipid nanoparticles based on Precirol® ATO to evaluate their effect on the physicochemical properties of these latter. Moreover, drug loading and skin permeation of Econazole nitrate, chosen as a lipophilic model drug, were evaluated as well. The obtained nanosystems, prepared by high shear homogenization method, had a mean diameter ranging from 180 to 280 nm and showed an encapsulation efficiency of about 100%. Ex vivo permeation results demonstrated a parabolic correlation between permeation effect and chain length of the fatty esters present in the lipid nanoparticles formulated in hydrophilic gels. The maximum flux of drug was observed for the nanoparticles containing esters with 17 and 19 carbon atoms, suggesting that these formulations may constitute a potential carrier for topical delivery of econazole nitrate.

Item Type:Article
ID Code:3523
Status:Published
Refereed:Yes
Uncontrolled Keywords:Fatty acid ester, lipid nanoparticle, econazole nitrate, skin permeation
Subjects:Area 03 - Scienze chimiche > CHIM/04 Chimica industriale
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:The Pharmaceutical Society of Japan
eISSN:1347-5223
Deposited On:25 Jan 2010 12:03

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page