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Genetic and environmental factors in human osteoporosis from Sub-Saharan to Mediterranean areas

Musumeci, Maria and Vadalà, Gianluca and Tringali, Giovanni and Insirello, Elio and Roccazzello, Anna Maria and Simpore, Jacques and Musumeci, Salvatore (2009) Genetic and environmental factors in human osteoporosis from Sub-Saharan to Mediterranean areas. Journal of Bone and Mineral Metabolism, Vol. 27 (4), p. 424-434. eISSN 1435-5604. Article.

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DOI: 10.1007/s00774-009-0041-2

Abstract

The aim of this study was to determine the prevalence of known gene polymorphisms associated with osteoporosis in postmenopausal normal women from Burkina Faso and Sicily, compared to postmenopausal Sicilian women with osteoporosis, and to establish the weight of environmental factors in the mechanism of osteoporosis. Bone mass density (BMD) was measured by phalangeal quantitative ultrasound (QUS) in Burkinabe woman and by the dual X-ray absorptiometry at the femoral neck in Sicilian women. The polymorphisms of the vitamin D receptor (VDR) gene, estrogen receptor (ESR) gene, calcitonin receptor (CTR) gene and COL1A1 collagen gene were characterized by PCR. The social characteristics of studied women were evaluated by a specific questionnaire. The observed percentages of single specific polymorphisms did not differ from that expected with exception of VDR B allele and ESR X and P allele in Burkinabe and Sicilian women, respectively. Association analyses and multivariate two-step regression model of social and molecular parameters, demonstrated that in comparison to the VDR, ESR, CTR polymorphisms, physical activities and healthy diet, associated with outdoor work are the best favourable prognostic factors for osteoporosis. A diet rich in calcium, other minerals and vitamin D in association with physical activity represents the most effective way to maintain not only a healthy bone structure but also an acceptable BMD. This is particularly true for Sub-Saharan women.

Item Type:Article
ID Code:3519
Status:Published
Refereed:Yes
Uncontrolled Keywords:Osteoporosis, polymorphisms, Sub-Saharan area, Mediterranean area, postmenopausal women
Subjects:Area 06 - Scienze mediche > MED/38 Pediatria generale e specialistica
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Springer Japan
eISSN:1435-5604
Deposited On:25 Jan 2010 09:53

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