Synthesis and cytotoxicity of novel hexahydrothieno-cycloheptapyridazinone derivatives

Pau, Amedeo and Murineddu, Gabriele and Asproni, Battistina and Murruzzu, Caterina and Grella, Giuseppe Enrico and Pinna, Gérard Aimé and Curzu, Maria Michela and Marchesi, Irene and Bagella, Luigi Marco (2009) Synthesis and cytotoxicity of novel hexahydrothieno-cycloheptapyridazinone derivatives. Molecules, Vol. 14 (9), p. 3494-3508. ISSN 1420-3049. Article.

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DOI: 10.3390/molecules14093494

Abstract

Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothieno-cycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.

Item Type:	Article
ID Code:	3507
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Pyridazinones, synthesis, cytotoxicity
Subjects:	Area 05 - Scienze biologiche > BIO/10 Biochimica Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Scienze biomediche 001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:	Molecular Diversity Preservation International
ISSN:	1420-3049
Deposited On:	22 Jan 2010 13:01

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