Pau, Amedeo and Murineddu, Gabriele and Asproni, Battistina and Murruzzu, Caterina and Grella, Giuseppe Enrico and Pinna, Gérard Aimé and Curzu, Maria Michela and Marchesi, Irene and Bagella, Luigi Marco (2009) Synthesis and cytotoxicity of novel hexahydrothieno-cycloheptapyridazinone derivatives. Molecules, Vol. 14 (9), p. 3494-3508. ISSN 1420-3049. Article.
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Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothieno-cycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.
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