UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Oxaliplatin, irinotecan, and fluorouracil/folinic acid in advanced gastric cancer: a multicenter phase II trial of the Southern Italy Cooperative Oncology Group

Comella, Pasquale and Lorusso, Vito and Maiorino, Luigi and Casaretti, Rossana and Cannone, Michele and Massidda, Bruno and Putzu, Carlo and Leo, Silvana and Roselli, Mario and Mancarella, Sergio and Palmeri, Sergio and Greco, Ettore and Vessia, Giacomo and Sandomenico, Claudia and Franco, Luca (2009) Oxaliplatin, irinotecan, and fluorouracil/folinic acid in advanced gastric cancer: a multicenter phase II trial of the Southern Italy Cooperative Oncology Group. Cancer Chemotherapy and Pharmacology, Vol. 64 (5), p. 893-899. eISSN 1432-0843. Article.

Full text not available from this repository.

DOI: 10.1007/s00280-009-0938-4

Abstract

Methods. Patients with unresectable or metastatic gastric cancer, unexposed to palliative chemotherapy, received oxaliplatin 85 mg/m2 iv and irinotecan 150 mg/m2 iv on day 1, 6S-folinic acid 250 mg/m2 iv and fluorouracil 750 mg/m2 iv on day 2, every 2 weeks. Response rate (RR) was assessed after a minimum of four cycles, and treatment continued up to 12 cycles.
Results. Sixty-three patients were treated, with a median of eight (range 1–12) cycles/patient. Two complete and 19 partial responses were registered (RR 33% [95% CI, 22–46%]). Median progression-free survival was 7.5 (95% CI, 5.6–9.4) months, and median overall survival was 12.1 (95% CI, 10.8–13.4) months. Most common grade ≥3 toxicities were neutropenia (59%), febrile neutropenia (7%), vomiting (20%), and diarrhoea (10%). All-grade neurotoxicity affected 33% of patients.
Conclusions. Oxaliplatin, irinotecan, and fluorouracil/folinic acid administered every 2 weeks are safe and active in advanced gastric cancer.

Item Type:Article
ID Code:3505
Status:Published
Refereed:Yes
Uncontrolled Keywords:Gastric cancer, fluorouracil, irinotecan, oxaliplatin, triplet regimen
Subjects:Area 06 - Scienze mediche > MED/06 Oncologia medica
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
Publisher:Springer Berlin / Heidelberg
eISSN:1432-0843
Deposited On:21 Jan 2010 13:09

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page