Fadda, Giovanni Maria and Santeufemia, Davide Adriano and Cossu Rocca, Paolo Alessandro and Bardino, Gianfranco and Costantino, Salvatore and Sanna, Giovanni and Sarobba, Maria Giuseppa and Farris, Antonio (2009) Fulminant liver failure in a patient affected by polycystic liver disease and liver metastases from breast carcinoma. Tumori, Vol. 95 (4), p. 557-661. ISSN 0300-8916. Article.
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Background. Polycystic liver disease (PLD) is a rare, congenital, benign condition characterized by the presence of multiple bile-duct-derived epithelial cysts in the liver parenchyma. The disease is usually asymptomatic, but cyst growth can result in complications such as ascites, esophageal varices, jaundice and hepatic failure. The exact mechanism leading to cyst growth is unclear, but estrogenic stimulation and paracrine action of vascular endothelial growth factor (VEGF) are thought to play a role in the growth of cyst epithelium.
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