Todesco, Sara Anna Rita (2010) Effetti indotti dalla stimolazione elettrica trigeminale transcutanea sull’attività EEG di soggetti sani e di pazienti con epilessia farmacoresistente. Doctoral Thesis.
Aim: trigeminal nerve stimulation (TNS) induces an antiepileptic effect in experimentally induced epileptic animals, and a significant reduction seizures frequency in refractory partial epilepsy (RPE) patients. As far as we know, no information is yet available on the influence exerted by acute TNS on EEG activity of humans. We investigated the TNS effects on EEG activity of healthy subjects and RPE patients. Methods: ten patients and five healthy subjects were enrolled. Digital EEG signal was acquired before, during and after unilateral and bilateral non-painful TNS. EEG spectral analysis was performed. ANOVA for repeated measures was conducted to compare data before and after TNS.
Relative power was represented with topographic maps to characterize the regional
differences. Results: In healthy subjects the general power spectra was significantly
increased following TNS, compared to baseline recording. In patients, a significant
increase of mean frequency (mF) (p<0.01) and of fast activity (p<0.05) and significant
decrease of theta band (p<0.01) during post-stimulus intervals compared to baseline were
found. The most relevant TNS-induced EEG changes were localized at frontal-temporal
derivations (theta power reduction p<0.0001; mF increase p<0.0002 ), where the epileptic
foci were sited.
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