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Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties

Pinna, Gérard Aimé and Loriga, Giovanni and Murineddu, Gabriele and Grella, Giuseppe Enrico and Mura, Massimo and Vargiu, Laura and Murgioni, Chiara and La Colla, Paolo (2001) Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties. Chemical and Pharmaceutical Bulletin, Vol. 49 (11), p. 1406-1411. eISSN 1347-5223. Article.

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DOI: 10.1248/cpb.49.1406

Abstract

In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.

Item Type:Article
ID Code:346
Status:Published
Refereed:Yes
Uncontrolled Keywords:Delavirdine analogue, arylpyrrole motif synthesis, anti-human immunodeficiency virus (HIV) activity
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:The Pharmaceutical Society of Japan
eISSN:1347-5223
Deposited On:18 Aug 2009 10:02

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