Pinna, Gérard Aimé and Loriga, Giovanni and Murineddu, Gabriele and Grella, Giuseppe Enrico and Mura, Massimo and Vargiu, Laura and Murgioni, Chiara and La Colla, Paolo (2001) Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties. Chemical and Pharmaceutical Bulletin, Vol. 49 (11), p. 1406-1411. eISSN 1347-5223. Article.
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In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.
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