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Cell sex determines anoikis resistance in vascular smooth muscle cells

Straface, Elisabetta and Vona, Rosa and Gambardella, Lucrezia and Ascione, Barbara and Marino, Maria and Bulzomi, Paola and Canu, Silvia and Coinu, Rita and Rosano, Giuseppe and Marloni, Walter and Franconi, Flavia (2009) Cell sex determines anoikis resistance in vascular smooth muscle cells. FEBS Letters, Vol. 583 (21), p. 3448-3454. ISSN 0014-5793. Article.

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DOI: 10.1016/j.febslet.2009.09.052


Sexual dimorphism, detectable in vascular smooth muscle cells freshly isolated from aorta of male and female rats, is associated with a different susceptibility to radiation-induced apoptosis. In this work we investigated the mechanism underlying this difference and discovered that, in comparison with cells from male rats, cells from female rats show adhesion-associated resistance to apoptosis, the so called anoikis resistance. This is apparently due to a more adhering phenotype, characterized by a well organized actin microfilament cytoskeleton and to an increased phosphorylated focal adhesion kinase, and, more importantly, to a higher propensity to undergo survival by autophagy.

Item Type:Article
ID Code:3399
Uncontrolled Keywords:Reactive oxygen species, vascular smooth muscle cells, apoptosis, gender, anoikis, cell adhesion, autophagy, senescence
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 02 Centri > Centro di eccellenza interdisc. sviluppo ricerca biotecnologica e studio biodiversità della Sardegna e dell'area mediterranea
001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
002 Altri enti e centri di ricerca del Nord Sardegna > Istituto nazionale biostrutture e biosistemi, Unità di ricerca, Sassari
Copyright Holders:© 2009 Federation of European Biochemical Societies
Deposited On:14 Jan 2010 13:30

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