Straface, Elisabetta and Vona, Rosa and Gambardella, Lucrezia and Ascione, Barbara and Marino, Maria and Bulzomi, Paola and Canu, Silvia and Coinu, Rita and Rosano, Giuseppe and Marloni, Walter and Franconi, Flavia (2009) Cell sex determines anoikis resistance in vascular smooth muscle cells. FEBS Letters, Vol. 583 (21), p. 3448-3454. ISSN 0014-5793. Article.
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Sexual dimorphism, detectable in vascular smooth muscle cells freshly isolated from aorta of male and female rats, is associated with a different susceptibility to radiation-induced apoptosis. In this work we investigated the mechanism underlying this difference and discovered that, in comparison with cells from male rats, cells from female rats show adhesion-associated resistance to apoptosis, the so called anoikis resistance. This is apparently due to a more adhering phenotype, characterized by a well organized actin microfilament cytoskeleton and to an increased phosphorylated focal adhesion kinase, and, more importantly, to a higher propensity to undergo survival by autophagy.
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