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Neuropsycological gender differences in healthy individuals and in pediatric neurodevelopmental disorders: a role for SNAP-25

Ghezzo, Alessandro and Guerini, Franca R. and Bolognesi, Elisabetta and Matteoli, Michela and Manca, Salvatorica and Sotgiu, Stefano and Bejor, Maurizio and Clerici, Mario and Chiappedi, Matteo (2009) Neuropsycological gender differences in healthy individuals and in pediatric neurodevelopmental disorders: a role for SNAP-25. Medical Hypotheses, Vol. 73 (6), p. 978-980. ISSN 0306-9877. Article.

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DOI: 10.1016/j.mehy.2009.05.045

Abstract

Synaptosomal-associated protein of 25 KD (SNAP-25) is a protein that participates in synaptic vesicle exocytosis through the formation of a SNARE complex; SNAP-25 also plays a pivotal role in modulating calcium homeostasis through negative regulation of voltage-gated calcium channels. SNAP-25 has been involved in different neuropsychiatric disorders, including attention deficit hyperactivity disorder. There are well known physiological gender differences in many neuropsychological skills, and there are even more striking gender differences in patients with attention deficit hyperactivity disorder and autism spectrum disorders. We hypothesize that these differences are the result of a mechanism involving SNAP-25 polymorphisms and its differential expression in specific brain areas.

Item Type:Article
ID Code:3387
Status:Published
Refereed:Yes
Uncontrolled Keywords:Synaptosomal-associated protein, neuropsychiatric disorders, hyperactivity, autism
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 03 Istituti > Neuropsichiatria infantile
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Elsevier
ISSN:0306-9877
Deposited On:14 Jan 2010 10:37

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