Ghezzo, Alessandro and Guerini, Franca R. and Bolognesi, Elisabetta and Matteoli, Michela and Manca, Salvatorica and Sotgiu, Stefano and Bejor, Maurizio and Clerici, Mario and Chiappedi, Matteo (2009) Neuropsycological gender differences in healthy individuals and in pediatric neurodevelopmental disorders: a role for SNAP-25. Medical Hypotheses, Vol. 73 (6), p. 978-980. ISSN 0306-9877. Article.
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Synaptosomal-associated protein of 25 KD (SNAP-25) is a protein that participates in synaptic vesicle exocytosis through the formation of a SNARE complex; SNAP-25 also plays a pivotal role in modulating calcium homeostasis through negative regulation of voltage-gated calcium channels. SNAP-25 has been involved in different neuropsychiatric disorders, including attention deficit hyperactivity disorder. There are well known physiological gender differences in many neuropsychological skills, and there are even more striking gender differences in patients with attention deficit hyperactivity disorder and autism spectrum disorders. We hypothesize that these differences are the result of a mechanism involving SNAP-25 polymorphisms and its differential expression in specific brain areas.
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