Abstract

Haemoglobin (Hb) phenotypes have been studied in 100 wild European mouflons living on the island of Sardinia by means of isoelectric focusing (pH 6.7-7.7 range) of the native tetramers, acid-urea-Triton gel-electrophoresis, and reversedphase HPLC of globin chains. The result indicates the presence of two ß-globin alleles one of which, corresponding to the ß^B, being the most common (f=0.94). None were carriers of the earlier described Hb A. The new Hb was provisionally named Hb M. Severely anaemic mouflons were able to synthesize Hb C at expense of the Hb B alone, thus suggesting structural and physiological homologies between mouflon ß^B and sheep ß^A globin genes, and between the newly observed ß^M allele and the ß^B of the domestic Sardinian sheep.

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