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Involvement of adenosine A1 and A2A receptors in (-)-linalool-induced antinociception

Peana, Alessandra Tiziana and Rubattu, Paolo and Piga, Gian Giorgio and Fumagalli, Silvia and Boatto, Gianpiero and Pippia, Proto Gavino and Demontis, Maria Graziella (2006) Involvement of adenosine A1 and A2A receptors in (-)-linalool-induced antinociception. Life Sciences, Vol. 78 (21), p. 2471-2474. ISSN 0024-3205. Article.

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DOI: 10.1016/j.lfs.2005.10.025


In recent studies performed in our laboratory we have shown that acute administration of (-)-linalool, the natural occurring enantiomer in essential oils, possesses anti-inflammatory, antihyperalgesic and antinociceptive effects in different animal models. The antihyperalgesic and antinociceptive effects of (-)-linalool have been ascribed to its capacity in stimulating the opioidergic, cholinergic and dopaminergic systems, as well as to its interaction with K+ channels, or to its local anaesthetic activity and/or to the negative modulation of glutamate transmission. Activation of A1 or A2A receptors has been shown to induce antinociceptive effects, and the possible involvement of adenosine in (-)-linalool antinociceptive effect, has not been elucidated yet. Therefore, in the present study, we have investigated the effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a selective adenosine A1 receptor antagonist and the effects of 3,7-dimethyl-1-propargilxanthine (DMPX), a selective adenosine A2A receptor antagonist on the antinociception of (-)-linalool in mice, measured in the hot-plate test. Both DPCPX (0.1 mg/kg; i.p.) and DMPX (0.1 mg/kg; i.p.) pre-treatment significantly depressed the antinociceptive effect of (-)-linalool at the highest doses tested. These findings demonstrated that the effect of (-)-linalool on pain responses is, at least partially, mediated by the activity of adenosine A1 and A2A receptors.

Item Type:Article
ID Code:310
Uncontrolled Keywords:(-)-Linalool, essential oil, adenosine A1 receptor antagonist, adenosine A2A receptor antagonist, antinociceptive activity, hot-plate test
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Copyright Holders:© 2005 Elsevier
Additional Information:Pubblicato online 15 dicembre 2005.
Deposited On:18 Aug 2009 10:02

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