Hadjisterkotis, Eleftherios and Manca, Laura and Naitana, Salvatore and Masala, Bruno Lucio (1995) A Comparative study on the haemoglobin polymorphism of domestic sheep of the islands of Chios, Cyprus and Sardinia. Comparative Biochemistry and Physiology. Part A: Physiology, Vol. 112 (3-4), p. 547-552. ISSN 1096-4940. Article.
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Different alleles at the two linked α-globin loci are present in sheep: Iα113Leu and IIα113Leu, Iα8Ala,113Leu, Iα15Asp,113Leu, and IIα113His. Triplicated α-gene haplotypes are also common. Six different β-globins (A, B, E, G, H, and I) contribute to the Hb polymorphism. A comparative study on the biochemical polymorphism of α- and β-globins in pure sheep breeds of the Mediterranean islands of Chios, Cyprus, and Sardinia is described. Cyprus and Sardinia breeds have the lower frequency of α-globin variants. Chios sheep possess the high 0.40 frequency of the Iα8Ala,113Leu-IIα113His arrangement. No α-gene triplications were observed amongst Chios and Cyprus breeds. None showed the Iα15Asp,113Leu variant. The βB allele largely predominates; the frequency of the βA was lower (f = 0.03) amongst Sarda sheep that also possess the βI variant. A novel βB-globin variant was observed in the Chios breed. Both natural and artificial selection may be the cause for these differences.
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