Kinetics of the ontogenic and reversible hemoglobin switching in the mouflon (Ovis musimon) and sheep × mouflon hybrid

Kinetics of the ontogenic and reversible hemoglobin switching in the mouflon (Ovis musimon) and sheep × mouflon hybrid

Masala, Bruno Lucio and Manca, Laura and Cocco, Elena and Ledda, Sergio and Naitana, Salvatore (1991) Kinetics of the ontogenic and reversible hemoglobin switching in the mouflon (Ovis musimon) and sheep × mouflon hybrid. Comparative Biochemistry and Physiology. Part A: Physiology, Vol. 100 (3), p. 675-680. ISSN 1096-4940. Article.

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DOI: 10.1016/0300-9629(91)90388-S

Abstract

1. 1. Hemoglobin (Hb) switching in the perinatal life of wild mouflon (Ovis musimon) was characterized by the replacement of Hb F by 60% levels of Hb C, and subsequently of Hb C by Hb B.
2. 2. The recently discovered Hb M variant was not replaced by Hb C; thus, Hb BM heterozygote newborns synthesized 30% Hb C at the expense of Hb B.
3. 3. Hybrid B mouflon × B sheep synthesized only 5% Hb C at birth but were able to produce 30% Hb C in adult life following induced anemia.
4. 4. Adult BB and BM mouflons, after the same extent of induced anemia, synthesized HB C levels similar to those produced at birth. The results indicate a mouflon β-globin gene cluster arrangement similar to those of sheep and goat, the β^C gene having an intermediate expression. Results also suggest a selective disadvantage in hybrid animals.

Item Type:	Article
ID Code:	3078
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Hb switching, Hb M variant, hybrid animals
Subjects:	Area 07 - Scienze agrarie e veterinarie > VET/10 Clinica ostetrica e ginecologia veterinaria Area 07 - Scienze agrarie e veterinarie > VET/02 Fisiologia veterinaria Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari 001 Università di Sassari > 01 Dipartimenti > Patologia e clinica veterinaria 001 Università di Sassari > 01 Dipartimenti > Biologia animale
Publisher:	Pergamon / Elsevier
ISSN:	1096-4940
Additional Information:	Pubblicato online il 21 marzo 2003.
Deposited On:	01 Oct 2009 12:49

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