High-performance liquid chromatography of globin chains in the identification of human globin gene abnormalities

Masala, Bruno Lucio and Manca, Laura (1990) High-performance liquid chromatography of globin chains in the identification of human globin gene abnormalities. Biophysical Chemistry, Vol. 37 (1-3), p. 225-230. ISSN 0301-4622. Article.

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DOI: 10.1016/0301-4622(90)88021-J

Abstract

This article summarizes experience and data obtained using a previously developed reverse-phase high-performance liquid chromatography method (J.B. Shelton, J.R. Shelton and W.A. Schroeder, J. Liq. Chromatogr. 7 (1984) 1969) in the study of a number of hemoglobinopathies in the Sardinian population. The occurrence and incidence of several abnormal hemoglobins are described, as well as aspects of the expression of abnormal γ-globin gene arrangements and thalassemic genes.

Item Type:	Article
ID Code:	3073
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	HPLC, globin, hemoglobinopathy, (Human)
Subjects:	Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
Publisher:	Elsevier
ISSN:	0301-4622
Additional Information:	Pubblicato online il 15 novembre 2001.
Deposited On:	01 Oct 2009 09:50

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