UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
The sequence and phylogenesis of the α-globin genes of Barbary sheep (Ammotragus lervia), goat (Capra hircus), European mouflon (Ovis aries musimon) and Cyprus mouflon (Ovis aries ophion)

Pirastru, Monica and Multineddu, Chiara and Mereu, Paolo and Sannai, Mara and El-Sherbini, El Said and Hadjisterkotis, Eleftherios and Náhlik, András and Franceschi, Paul and Manca, Laura and Masala, Bruno Lucio (2009) The sequence and phylogenesis of the α-globin genes of Barbary sheep (Ammotragus lervia), goat (Capra hircus), European mouflon (Ovis aries musimon) and Cyprus mouflon (Ovis aries ophion). Comparative Biochemistry and Physiology. Part D: Genomics and Proteomics, Vol. 4 (3), p. 168-173. eISSN 1744-117X. Article.

Full text not available from this repository.

DOI: 10.1016/j.cbd.2009.02.002

Abstract

In order to investigate the polymorphism of α-globin chain of hemoglobin amongst caprines, the linked Iα and IIα globin genes of Barbary sheep (Ammotragus lervia), goat (Capra hircus), European mouflon (Ovis aries musimon), and Cyprus mouflon (Ovis aries ophion) were completely sequenced, including the 5′ and 3′ untranslated regions. European and Cyprus mouflons, which do not show polymorphic α globin chains, had almost identical α globin genes, whereas Barbary sheep exhibit two different chains encoded by two nonallelic genes. Four different α genes were observed and sequenced in goat, validating previous observations of the existence of allelic and nonallelic polymorphism. As in other vertebrates, interchromosomal gene conversion appears to be responsible for such polymorphism. Evaluation of nucleotide sequences at the level of molecular evolution of the Iα-globin gene family in the caprine taxa suggests a closer relationship between the genus Ammotragus and Capra. Molecular clock estimates suggest sheep-mouflon, goat-aoudad, and ancestor-caprine divergences of 2.8, 5.7, and 7.1 MYBP, respectively.

Item Type:Article
ID Code:3072
Status:Published
Refereed:Yes
Uncontrolled Keywords:Ammotragus lervia, Capra hircus, Ovis aries musimon, Ovis aries ophion, α-globin gene, α-globin, sequencing, phylogeny
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:001 Università di Sassari > 02 Centri > Centro di eccellenza interdisc. sviluppo ricerca biotecnologica e studio biodiversità della Sardegna e dell'area mediterranea
001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
Publisher:Elsevier
eISSN:1744-117X
Deposited On:30 Sep 2009 13:49

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page