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Genotype at the MTNR1A locus and response to melatonin treatment in Sarda lambs

Mura, Maria Consuelo and Luridiana, Sebastiano and Daga, Cinzia and Bini, Pier Paolo and Carcangiu, Vincenzo (2009) Genotype at the MTNR1A locus and response to melatonin treatment in Sarda lambs. Italian Journal of Animal Science, Vol. 8 (Suppl. 2), p. 114-116. ISSN 1828-051X. Article.

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With the aim to evaluate the effect of melatonin treatment and melatonin receptor 1A (MTNR1A) genotype on advance of puberty, 423 Sarda lambs were chosen. On June 26th, they were divided into three groups, each of 141 animals (groups 0, 1, and 2), on the basis of live weight. On June 30th, animals in group 1 received a single implant (18 mg melatonin), while group 2 received two implants. Group 0 was untreated. Thirty-five days after treatment (August 4th), rams were introduced and after 40 days they were removed. From January 1st to February 10th lambing dates were recorded. Genomic DNA was extracted and subjected to PCR for the amplification of exon II and then digested with enzymes MnlI and RsaI and placed into +/+, +/−, or −/− group for MnlI and C/C, C/T, or T/T group for RsaI. Samples were cloned and sequenced. Data obtained were subjected to χ2 test in order to evaluate the difference in fertility among groups and the link between genotype and reproductive activity. Genotype +/+ and C/C showed the highest incidence. Treated groups showed a higher number of lambing at 10th February compared to control group (P<0.04). Melatonin treatment results more efficient in +/+ genotype.

Item Type:Article
ID Code:3015
Uncontrolled Keywords:MTNR1A locus, Sarda lambs, melatonin implants, Sardinia
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/02 Fisiologia veterinaria
Area 07 - Scienze agrarie e veterinarie > AGR/17 Zootecnica generale e miglioramento genetico
Divisions:001 Università di Sassari > 01 Dipartimenti > Biologia animale
Publisher:Avenue media on behalf of Scientific Association of Animal Production (ASPA)
Publisher Policy:Depositato per gentile concessione dell'ASPA
Additional Information:Relazione presentata al 18. Congresso nazionale ASPA, Palermo, 9-12 giugno 2009.
Deposited On:18 Sep 2009 10:54

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