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Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils

Peana, Alessandra Tiziana and D'Aquila, Paolo Stefano and Panin, Francesca and Serra, Gino and Pippia, Proto Gavino and Moretti, Mario Domenico Luigi (2002) Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils. Phytomedicine, Vol. 9 (8), p. 721-726. ISSN 0944-7113. Article.

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DOI: 10.1078/094471102321621322

Abstract

Linalool and linalyl acetate are the principal components of many essential oils known to possess several biological activities, attributable to these monoterpene compounds. In this work, we evaluated individually the anti-inflammatory properties of (–) linalool, that is, the natural occurring enantiomer, and its racemate form, present in various amounts in distilled or extracted essential oils. Because in the linalool-containing essential oils, linalyl acetate, is frequently present, we also examined the anti-inflammatory action of this monoterpene ester. Carrageenin-induced edema in rats was used as a model of inflammation. The experimental data indicate that both the pure enantiomer and its racemate induced, after systemic administration, a reduction of edema. Moreover, the pure enantiomer, at a dose of 25 mg/kg, elicited a delayed and more prolonged effect, while the racemate form induced a significant reduction of the edema only one hour after carrageenin administration. At higher doses, no differences were observed between the (–) enantiomer and the racemate; a further increase in the dose of both forms did not result in an increased effect at any time of observation. The effects of equi-molar doses of linalyl acetate on local edema were less relevant and more delayed than that of the corresponding alcohol. These finding suggest a typical pro-drug behavior of linalyl acetate. The results obtained indicate that linalool and the corresponding acetate play a major role in the anti-inflammatory activity displayed by the essential oils containing them, and provide further evidence suggesting that linalool and linalyl acetate-producing species are potentially anti-inflammatory agents.

Item Type:Article
ID Code:301
Status:Published
Refereed:Yes
Uncontrolled Keywords:(–) Linalool, (±) linalool, linalyl acetate, essential oil, anti-inflammatory activity
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Urban & Fischer / Elsevier
ISSN:0944-7113
Copyright Holders:© 2002 Urban & Fischer
Deposited On:18 Aug 2009 10:02

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