Giola, L. and Rizzu, D. and Zanetti, Stefania Anna Lucia (1978) Attività antibatterica in vitro della fosfonomicina. Giornale di batteriologia, virologia ed immunologia, Vol. 71 (1-6), p. 34-40. ISSN 0390-5462. Article.
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We have studied the "in vitro" antibacterial activity of phosphonomycin against 93 freshly isolated bacterial strains. Phosphonomycin posses a good activity mainly against Gram positive bacteria. A marked increase in the antibacterial activity "in vitro" is obtained when phosphonomycin is combined with other antibitoics having a similar mechanism of action (i.e. inhibition of cell-wall synthesis). We have also determined the frequency of phosphonomycin-resistant mutants in some of the strains tested for antibacterial activity. High frequency of resistant strains have found in Klebsiella spp.
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