Zanetti, Stefania Anna Lucia and Fiori, Pier Luigi and Pinna, Antonio <1963- > and Usai, Stefania and Carta, Francesco and Fadda, Giovanni (1995) Susceptibility of Acanthamoeba castellanii to contact lens disinfecting solutions. Antimicrobial Agents and Chemotherapy, Vol. 39 (7), p. 1596-1598. eISSN 1098-6596. Article.
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A corneal isolate of Acanthamoeba castellanii was exposed to commercial contact lens disinfecting solutions containing hydrogen peroxide, benzalkonium chloride, polyaminopropyl biguanide, polyquaternium 1, and chlorhexidine-thimerosal. The minimum trophozoite amebicidal concentration and exposure times required to kill trophozoites and cysts were determined. Solutions containing hydrogen peroxide or chlorhexidine-thimerosal were active against both trophozoites and cysts. The benzalkonium chloride-based solution was effective only against trophozoites. Solutions containing polyaminopropyl biguanide or polyquaternium 1 were completely ineffective. The need for adequate exposure times must be stressed.
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