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Adhesiveness of Bacillus subtilis strains to epithelial cells cultured in vitro

Angioi, A. and Zanetti, Stefania Anna Lucia and Sanna, Alberto and Delogu, Giovanni and Fadda, Giovanni (1995) Adhesiveness of Bacillus subtilis strains to epithelial cells cultured in vitro. Microbial Ecology in Health and Disease, Vol. 8 (2), p. 71-77. eISSN 1651-2235. Article.

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Abstract

The use of pharmaceutical preparations containing spores of Bacillus subtilis or other bacterial species in the treatment and prophylaxis of intestinal disorders associated with antibiotic therapy or diarrhoea of various origin is widespread and has been supported by encouraging results. However, the mechanism by which such an action is manifested in vivo is still not well defined. We carried out a study using B. subtilis spores present in a commercial preparation and treated in vitro, to mimic physiological conditions following oral consumption. Tests were carried out to evaluate the capacity of microorganisms to colonise the surface of eukaryotic (Caco-2 and HEp-2) cells. The bacteria were assayed both in the spored phase, and following stimulation of germination by exposure to low pH values (as in the case of gastric juice) or again with exposure to high temperatures. B. subtilis adhered to the surface of the eukaryotic cells, the degree of adhesion varying in relation to the different physiological phases of the bacterial cell.

Item Type:Article
ID Code:2938
Status:Published
Refereed:Yes
Uncontrolled Keywords:Bacillus subtilis, adhesive properties
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Informa Healthcare
eISSN:1651-2235
Deposited On:09 Sep 2009 10:26

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