In-vitro activity of 3-azinomethyl-rifamycin (SPA-S-565) against Chlamydia trachomatis

In-vitro activity of 3-azinomethyl-rifamycin (SPA-S-565) against Chlamydia trachomatis

Zanetti, Stefania Anna Lucia and Usai, Donatella and Nonis, A. and Fadda, Giovanni (1996) In-vitro activity of 3-azinomethyl-rifamycin (SPA-S-565) against Chlamydia trachomatis. Journal of Antimicrobial Chemotherapy, Vol. 37 (2), p. 357-359. eISSN 1460-2091. Article.

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DOI: 10.1093/jac/37.2.357

Abstract

The in-vitro activity of a 3-azinomethyl-rifamycin (SPA-S-565) against Chlamydia Trachomatis was compared to that of rifampicm and of erythromycin. The compound showed excellent activity for standard strains as well as isolates from patients with sexually transmitted diseases, being more active than the other drugs tested.
SPA-S-565 also showed a low frequency of emergence of resistance. Passage of standard strains at sub-inhibitory concentrations caused an increase in MIC values of rifampicin while those for SPA-S-565 remained unchanged.

Item Type:	Article
ID Code:	2936
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Sexually transmitted diseases, C. trachomatis
Subjects:	Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:	Oxford University Press
eISSN:	1460-2091
Copyright Holders:	© 1996 British Society for Antimicrobial Chemotherapy
Deposited On:	09 Sep 2009 09:44

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