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An Electron spin resonance study and antimicrobial activity of copper(II)-phenanthroline complexes

Zoroddu, Maria Antonietta and Zanetti, Stefania Anna Lucia and Pogni, Rebecca and Basosi, Riccardo (1996) An Electron spin resonance study and antimicrobial activity of copper(II)-phenanthroline complexes. Journal of Inorganic Biochemistry, Vol. 63 (4), p. 291-300. ISSN 0162-0134. Article.

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DOI: 10.1016/0162-0134(96)00015-3

Abstract

The antimicrobial activities of some copper(II) binary complexes with unsubstituted and different substituted phenanthroline ligands were investigated. A considerable increase in the biocidal activity of the ligands on being coordinated with the copper(II) ions was observed in terms of their minimum inhibitory concentration (MIC) values.

EPR measurements were performed at room and low temperature with the aim of gaining an insight into the structure/activity relationship of these complexes. Subtle differences in the chemical arrangement result in appreciable differences in the antimicrobial activity. Copper complexes with 2,9-dimethyl derivative phenanthrolines were observed to be more active against Staphylococcus aureus and Escherichia coli.

Item Type:Article
ID Code:2935
Status:Published
Refereed:Yes
Uncontrolled Keywords:Copper(II) binary complexes, EPR measurements, antimicrobial activity
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:Elsevier Science
ISSN:0162-0134
Deposited On:09 Sep 2009 09:07

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