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2-phenyl-6(7)-R-substituted quinoxalines N-oxides: synthesis, structure elucidation and antimicrobial activity

Loriga, Mario and Nuvole, Antonio Michele and Paglietti, Giuseppe and Fadda, Giovanni Maria and Zanetti, Stefania Anna Lucia (1990) 2-phenyl-6(7)-R-substituted quinoxalines N-oxides: synthesis, structure elucidation and antimicrobial activity. European Journal of Medicinal Chemistry, Vol. 25 (6), p. 527-532. ISSN 0223-5234. Article.

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DOI: 10.1016/0223-5234(90)90147-U


A certain number of isomeric 2-phenylquinoxalines N-oxides bearing substituents at position 6/7 were prepared in order to investigate anti-microbial activity. The effect of some electron-withdrawing groups seem to increase an anti-Trichomonas vaginalis activity in vitro. Structure elucidation of 6-acetyl-2-phenylquinoxaline was achieved by an unambiguous synthesis. 1H NMR spectra of N-oxides were examined in detail to establish structure of parent quinoxalines.

Item Type:Article
ID Code:2924
Uncontrolled Keywords:Quinoxaline-N-oxides, anti Trichomonas vaginalis activity, NMR structure elucidation
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Éditions scientifiques et médicales Elsevier / Elsevier Masson
Additional Information:Part of this work was presented as a poster communication at the French-Italian Joint Meeting on Medicinal Chemistry, Pisa (Italy), 22–26 September 1987.
Deposited On:07 Sep 2009 12:34

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