Loriga, Mario and Nuvole, Antonio Michele and Paglietti, Giuseppe and Fadda, Giovanni Maria and Zanetti, Stefania Anna Lucia (1990) 2-phenyl-6(7)-R-substituted quinoxalines N-oxides: synthesis, structure elucidation and antimicrobial activity. European Journal of Medicinal Chemistry, Vol. 25 (6), p. 527-532. ISSN 0223-5234. Article.
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A certain number of isomeric 2-phenylquinoxalines N-oxides bearing substituents at position 6/7 were prepared in order to investigate anti-microbial activity. The effect of some electron-withdrawing groups seem to increase an anti-Trichomonas vaginalis activity in vitro. Structure elucidation of 6-acetyl-2-phenylquinoxaline was achieved by an unambiguous synthesis. 1H NMR spectra of N-oxides were examined in detail to establish structure of parent quinoxalines.
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