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1,2,3-triazolo[4,5-h]quinolines: III: preparation and antimicrobial evaluation of 4-ethyl-4,7-dihydro-1(2)-R-1(2)H triazolo[4,5-h]quinolin-7-one-6-carboxylic acids as anti-infectives of the urinary tract

Sanna, Paolo Antonio and Carta, Antonio and Paglietti, Giuseppe and Zanetti, Stefania Anna Lucia and Fadda, Giovanni (1992) 1,2,3-triazolo[4,5-h]quinolines: III: preparation and antimicrobial evaluation of 4-ethyl-4,7-dihydro-1(2)-R-1(2)H triazolo[4,5-h]quinolin-7-one-6-carboxylic acids as anti-infectives of the urinary tract. Il Farmaco, Vol. 47 (7-8), p. 1001-1019. ISSN 0014-827X. Article.

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Abstract

Some 4-ethyl-1(2)-R-1(2)H-4,7-dihydro-triazolo[4,5-h]-quinolin-7-one-6- carboxylic acids were prepared as novel analogues of oxolinic acid, in order to discover the influence of the annelation position of the triazole ring on the antimicrobial activity that, in some isomers triazolo[4,5-f]quinoline carboxylic acids, is selective against Escherichia coli. Some interesting side reactions in the cyclization of 1(2)-R-1(2)H-benzotriazol-4-yl-aminomethylenemalonate are also described. The biological results indicate that this type of annelation is not profitable for antimicrobial activity.

Item Type:Article
ID Code:2920
Status:Published
Refereed:Yes
Uncontrolled Keywords:Carboxylic acids, antimicrobial activity, Escherichia coli
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Società chimica italiana
ISSN:0014-827X
Publisher Policy:Depositato per gentile concessione dell'Editore
Additional Information:Part of this work was presented as a poster communication at the 1. Congreso Conjunto Hispano-Italiano de Quimica Terapeutica - Granada, 19-22 September 1989, pag. 312.
Deposited On:04 Sep 2009 12:53

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