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Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains

Deidda, Delia and Lampis, Giorgio and Fioravanti, Rossella and Biava, Mariangela and Porretta, Giulio Cesare and Zanetti, Stefania Anna Lucia and Pompei, Raffaello (1998) Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrobial Agents and Chemotherapy, Vol. 42 (11), p. 3035-3037. eISSN 1098-6596. Article.

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Abstract

The pyrrole derivative BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl)methyl-pyrrole] was shown to possess strong inhibitory activity against both Mycobacterium tuberculosis and some nontuberculosis mycobacteria. BM212 was inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.

Item Type:Article
ID Code:2911
Status:Published
Refereed:Yes
Uncontrolled Keywords:BM212, antimycobacterial drugs, Mycobacterium tuberculosis
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:American Society for Microbiology
eISSN:1098-6596
Deposited On:03 Sep 2009 13:10

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