Pinna, Antonio <1963- > and Zanetti, Stefania Anna Lucia and Sotgiu, Stefano and Sechi, Leonardo Antonio and Fadda, Giovanni and Carta, Francesco (1999) Identification and antibiotic susceptibility of coagulase negative staphylococci isolated in corneal/external infections. British Journal of Ophthalmology, Vol. 83 (7), p. 771-773. eISSN 1468-2079. Article.
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AIMS. To identify and determine antibiotic susceptibility of coagulase negative staphylococci (CoNS) isolated from patients with chronic blepharitis, purulent conjunctivitis, and suppurative keratitis.
METHODS. A retrospective review of all culture positive cases of chronic blepharitis, purulent conjunctivitis, and suppurative keratitis between July 1995 and December 1996 was performed. Cases in which CoNS were the sole isolates were analysed. Species identification was performed by using a commercially available standardised biochemical test system. Antibiotic susceptibility to penicillin, gentamicin, tetracycline, erythromycin, ciprofloxacin, and teicoplanin was determined by agar disc diffusion (Kirby–Bauer method). Teicoplanin resistance was confirmed by agar dilution.
RESULTS. 42 Staphylococcus epidermidis, four S. warneri, three S. capitis, two S. hominis, one each of S. xylosus, S. simulans, S. equorum, and S. lugdunensis were identified. 37 CoNS were penicillin resistant, 12 gentamicin resistant, 28 tetracycline resistant, 18 erythromycin resistant, four ciprofloxacin resistant, and one teicoplanin resistant (MIC, 32 μg/ml). In total, 16 strains were resistant to three or more antibiotics.
CONCLUSION. Species of CoNS apart from S. epidermidis may be isolated from patients with corneal and external infection. Antibiotic susceptibility of CoNS is unpredictable and multiresistant strains are common. As a result, antibiotic susceptibility testing should be performed in all cases of clinically significant ocular infections caused by CoNS.
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