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Identification and antibiotic susceptibility of coagulase negative staphylococci isolated in corneal/external infections

Pinna, Antonio <1963- > and Zanetti, Stefania Anna Lucia and Sotgiu, Stefano and Sechi, Leonardo Antonio and Fadda, Giovanni and Carta, Francesco (1999) Identification and antibiotic susceptibility of coagulase negative staphylococci isolated in corneal/external infections. British Journal of Ophthalmology, Vol. 83 (7), p. 771-773. eISSN 1468-2079. Article.

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DOI: 10.1136/bjo.83.7.771

Abstract

AIMS. To identify and determine antibiotic susceptibility of coagulase negative staphylococci (CoNS) isolated from patients with chronic blepharitis, purulent conjunctivitis, and suppurative keratitis.
METHODS. A retrospective review of all culture positive cases of chronic blepharitis, purulent conjunctivitis, and suppurative keratitis between July 1995 and December 1996 was performed. Cases in which CoNS were the sole isolates were analysed. Species identification was performed by using a commercially available standardised biochemical test system. Antibiotic susceptibility to penicillin, gentamicin, tetracycline, erythromycin, ciprofloxacin, and teicoplanin was determined by agar disc diffusion (Kirby–Bauer method). Teicoplanin resistance was confirmed by agar dilution.
RESULTS. 42 Staphylococcus epidermidis, four S. warneri, three S. capitis, two S. hominis, one each of S. xylosus, S. simulans, S. equorum, and S. lugdunensis were identified. 37 CoNS were penicillin resistant, 12 gentamicin resistant, 28 tetracycline resistant, 18 erythromycin resistant, four ciprofloxacin resistant, and one teicoplanin resistant (MIC, 32 μg/ml). In total, 16 strains were resistant to three or more antibiotics.
CONCLUSION. Species of CoNS apart from S. epidermidis may be isolated from patients with corneal and external infection. Antibiotic susceptibility of CoNS is unpredictable and multiresistant strains are common. As a result, antibiotic susceptibility testing should be performed in all cases of clinically significant ocular infections caused by CoNS.

Item Type:Article
ID Code:2910
Status:Published
Refereed:Yes
Uncontrolled Keywords:Coagulase negative staphylococci (CoNS), ocular infections, antibiotic susceptibility
Subjects:Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Oftalmologia, Otorinolaringoiatria e Urologia
Publisher:BMJ Publishing Group
eISSN:1468-2079
Deposited On:03 Sep 2009 14:05

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