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PER-1 type beta-lactamase production in Acinetobacter baumannii is related to cell adhesion

Sechi, Leonardo Antonio and Karadenizli, Aynur and Deriu, Antonella and Zanetti, Stefania Anna Lucia and Kolayli, Fetiye and Balikci, Erdener and Vahaboglu, Haluk (2004) PER-1 type beta-lactamase production in Acinetobacter baumannii is related to cell adhesion. Medical Science Monitor, Vol. 10 (6), p. 180-184. eISSN 1643-3750. Article.

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BACKGROUND: Recently, the dissemination of ESBL (PER-1) among Acinetobacter isolates was reported in Turkish hospitals. We investigated the presence and the association of various virulence determinants in 20 Acinetobacter baumannii isolates, of which 13 were blaPER-1 positive.
MATERIAL/METHODS: Virulence tests were slime and hemolysin production, gelatinase and protease activity, biofilm formation, and Caco2 cell adhesion. RAPD analysis was also performed with ERIC primers.
RESULTS: None of the strains was positive for slime or hemolysin production and gelatinase or protease activity. A total of 16 strains, five of which were PER-1 gene negative, formed a biofilm on polymer surfaces. There was no relation between the presence of the PER gene and biofilm formation. On the other hand, nine strains (all PER-1 gene positive) were positive in adhesion experiments to Caco2 cell lines. All PER-negative strains were negative for cell adhesion.
CONCLUSIONS: This study indicates the existence of a relation between PER-1 gene and cell adhesion in Acinetobacter strains.

Item Type:Article
ID Code:2883
Uncontrolled Keywords:ESBL (PER-1), PER-1 gene, Acinetobacter strains
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Medical Science International
Deposited On:01 Sep 2009 12:39

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