Zanetti, Stefania Anna Lucia and Bua, Alessandra and Delogu, Giovanni and Pusceddu, Cinzia and Mura, Maria Stella Anna and Saba, Franca and Pirina, Pietro and Garzelli, Carlo and Vertuccio, Cono and Sechi, Leonardo Antonio and Fadda, Giovanni (2005) Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin. Clinical and Diagnostic Laboratory Immunology, Vol. 12 (9), p. 1135-1138. eISSN 1098-6588. Article.
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Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.
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