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Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

Zanetti, Stefania Anna Lucia and Bua, Alessandra and Delogu, Giovanni and Pusceddu, Cinzia and Mura, Maria Stella Anna and Saba, Franca and Pirina, Pietro and Garzelli, Carlo and Vertuccio, Cono and Sechi, Leonardo Antonio and Fadda, Giovanni (2005) Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin. Clinical and Diagnostic Laboratory Immunology, Vol. 12 (9), p. 1135-1138. eISSN 1098-6588. Article.

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DOI: 10.1128/CDLI.12.9.1135-1138.2005

Abstract

Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

Item Type:Article
ID Code:2880
Status:Published
Refereed:Yes
Uncontrolled Keywords:Pulmonary tuberculosis, Mycobacterium tuberculosis, HBHA
Subjects:Area 06 - Scienze mediche > MED/17 Malattie infettive
Area 06 - Scienze mediche > MED/10 Malattie dell'apparato respiratorio
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Tisiologia e malattie dell'apparato respiratorio
001 Università di Sassari > 03 Istituti > Malattie infettive e parassitarie
Publisher:American Society for Microbiology
eISSN:1098-6588
Deposited On:01 Sep 2009 09:22

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