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Mycobacterium avium subsp. paratuberculosis, genetic susceptibility to Crohn's disease, and Sardinians: the way ahead

Sechi, Leonardo Antonio and Gazouli, Maria and Ikonomopoulos, John and Lukas, John C. and Scanu, Antonio Mario and Ahmed, Niyaz and Fadda, Giovanni and Zanetti, Stefania Anna Lucia (2005) Mycobacterium aviumsubsp. paratuberculosis, genetic susceptibility to Crohn's disease, and Sardinians: the way ahead. Journal of Clinical Microbiology, Vol. 43 (10), p. 5275-5277. eISSN 1098-660X. Article.

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DOI: 10.1128/JCM.43.10.5275-5277.2005


The present study was performed to determine what proportion of people in Sardinia with or without Crohn's disease were infected with Mycobacterium avium subspecies paratuberculosis and had a preponderance of allelic variants of Nod2, an intracellular protein involved in Crohn's disease susceptibility. Genetic analysis of the alleles of the NOD2/CARD15 gene (insC3020, G908R, and R702W alleles), linked to susceptibility or genetic predisposition to Crohn's disease in humans, was carried out on specimens from 37 Crohn's disease patients and 34 patients without Crohn's disease. Our results show that more than 70 percent of people in Sardinia with Crohn's disease carry at least one of the susceptibility-associated NOD2/CARD15 alleles and were infected with Mycobacterium avium subspecies paratuberculosis.

Item Type:Article
ID Code:2879
Uncontrolled Keywords:Mycobacterium avium subsp. paratuberculosis, Crohn's disease, Sardinia
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 06 - Scienze mediche > MED/18 Chirurgia generale
Divisions:001 Università di Sassari > 03 Istituti > Clinica chirurgica generale e terapia chirurgica
001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
002 Altri enti e centri di ricerca del Nord Sardegna > ISOGEM-International Society for Genomic and Evolutionary Microbiology, Sassari
Publisher:American Society for Microbiology
Deposited On:31 Aug 2009 17:48

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