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The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice

Delogu, Giovanni and Sanguinetti, Maurizio and Posteraro, Brunella and Rocca, Stefano and Zanetti, Stefania Anna Lucia and Fadda, Giovanni (2006) The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice. Infection and Immunity, Vol. 74 (5), p. 3006-3011. eISSN 1098-5522. Article.

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DOI: 10.1128/IAI.74.5.3006-3011.2006

Abstract

We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.

Item Type:Article
ID Code:2871
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycobacterium tuberculosis, hbhA gene expression, epithelial cell infection, macrophage infection
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:001 Università di Sassari > 01 Dipartimenti > Patologia e clinica veterinaria
001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:American Society for Microbiology
eISSN:1098-5522
Deposited On:31 Aug 2009 13:06

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