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In vitro efficacy of Linezolid on clinical strains of Mycobacterium tuberculosis and other mycobacteria

Molicotti, Paola and Ortu, Silvia and Bua, Alessandra and Cannas, Sara and Sechi, Leonardo Antonio and Zanetti, Stefania Anna Lucia (2006) In vitroefficacy of Linezolid on clinical strains of Mycobacterium tuberculosis and other mycobacteria. New Microbiologica, Vol. 29 (4), p. 275-280. ISSN 1121-7138. Article.

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Abstract

Linezolid, an oxazolidinone that acts by inhibiting protein synthesis, was evaluated in strains of tuberculosis and non-tubercular mycobacteria resistant to one or more drugs isolated in northern Sardinia. The in vitro activity of Linezolid (Pfizer) was assessed on different isolates of Mycobacterium spp. from clinical samples by the Proportional Method. Linezolid demonstrated an excellent activity against the 24 strains of M. tuberculosis and against M. gordonae, M. marinum, M. aurum, M. phlei, and M. avium, with MIC values ranging from 0.5 to 2 μg/ml. Linezolid can be used in combination with the standard antitubercular medications, or as an effective therapeutic alternative in infections caused by M. tuberculosis or by other species of non-tubercular mycobacteria.

Item Type:Article
ID Code:2868
Status:Published
Refereed:Yes
Uncontrolled Keywords:Linezolid, Mycobacterium spp., proportional method, MIC
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Edizioni internazionali
ISSN:1121-7138
Deposited On:31 Aug 2009 11:43

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