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Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients

Sechi, Leonardo Antonio and Gazouli, Maria and Sieswerda, Lee E. and Molicotti, Paola and Ahmed, Niyaz and Ikonomopoulos, John and Scanu, Antonio Mario and Paccagnini, Daniela and Zanetti, Stefania Anna Lucia (2006) Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients. World Journal of Gastroenterology, Vol. 12 (44), p. 7161-7164. ISSN 1007-9327. Article.

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Abstract

AIM: To study the association between Crohn’s disease (CD), Mycobacterium avium subspecies paratuberculosis (MAP), and genetic factors by examining the role of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms (now SLC11A1) in Sardinian patients with CD and controls.
METHODS: Thirty-seven CD patients and 34 controls with no inflammatory bowel disease (IBD) were recruited at the University of Sassari after giving written consent. Six SCL11A1 polymorphisms previously reported to be the most significantly associated with IBD were searched. M. paratuberculosis was identified by IS900 PCR and sequencing. Logistic regression was used to calculate odds ratios (OR) for the associations among CD, presence of MAP, and 6 loci described above.
RESULTS: For the first time, a strong association was observed between polymorphisms at NRAMP1 locus 823C/T and CD. While CD was strongly associated with both NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated.
CONCLUSION: Combined with previous work on the NOD2/CARD15 gene, it is clear that the interplay of genetic, infectious, and immunologic factors in the etiology of CD is complex.

Item Type:Article
ID Code:2867
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycobacterium avium subspecies paratuberculosis, Crohn’s disease, SCL11A1 polymorphisms, Sardinia
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
002 Altri enti e centri di ricerca del Nord Sardegna > ISOGEM-International Society for Genomic and Evolutionary Microbiology, Sassari
Publisher:W J G Press
ISSN:1007-9327
Deposited On:31 Aug 2009 10:50

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