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Preliminary falsification of EIA screening is cost‐effective in the two‐step serodiagnosis of lyme disease

Piras, Maria Adriana and Aceti, Antonio (2000) Preliminary falsification of EIA screening is cost‐effective in the two‐step serodiagnosis of lyme disease. The Journal of Infectious Diseases, Vol. 181 (2), p. 802. ISSN 0022-1899. Article.

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DOI: 10.1086/315241

Abstract

We read with great interest the article by Trevejo et al. that described a simplified procedure for the laboratory diagnosis of Lyme disease (LD). The authors assumed as “certain” the clinical diagnosis of LD and on this basis calculated the sensitivity of 3 different diagnostic approaches. We suggest that there is some bias in the assumption that 25 EIA-positive serum samples plus 2 more Western immunoblot (WB)–confirmed samples, among equivocal results, sum up to a sensitivity of 41%, by the authors’ simplified method, in the early phase of LD. Similarly, the assumption was made that 39 EIA-positive sera, with no WB confirmation of equivocal results, give a sensitivity of 71% in the convalescent phase. The authors ignore that 6 (22%) of 27 and 23 (59%) of 39 EIA-positive results were disproved by WB. We cannot understand what scientific reasoning allows the omission of the WB-unconfirmed, EIA-equivocal results and the inclusion of WB-unconfirmed but EIApositive cases.

Item Type:Article
ID Code:2866
Status:Published
Refereed:Yes
Uncontrolled Keywords:Lyme disease (LD), EIA screening, viral infections
Subjects:Area 06 - Scienze mediche > MED/17 Malattie infettive
Divisions:001 Università di Sassari > 03 Istituti > Malattie infettive e parassitarie
Publisher:University of Chicago Press
ISSN:0022-1899
Copyright Holders:© 2000 by the Infectious Diseases Society of America
Publisher Policy:Depositato in conformità con la politica di copyright dell'Editore
Deposited On:31 Aug 2009 10:11

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