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Mycobacterium avium subspecies paratuberculosis infects and multiplies in enteric glial cells

Sechi, Leonardo Antonio and Rühl, Anne and Ahmed, Niyaz and Usai, Donatella and Paccagnini, Daniela and Felis, Giovanna E. and Zanetti, Stefania Anna Lucia (2007) Mycobacterium aviumsubspecies paratuberculosis infects and multiplies in enteric glial cells. World Journal of Gastroenterology, Vol. 13 (43), p. 5731-5735. ISSN 1007-9327. Article.

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Abstract

AIM: To establish the role of enteric glial cells during infection with Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn’s disease.
METHODS: In order to establish the role of enteric glial cells during infection with M. avium subspecies paratuberculosis (MAP) in Crohn’s disease, Map adhesion experiments on enteric glial cells were performed as well as expression analysis of Map sigma factors during infection.
RESULTS: In this study, for the fi rst time, we found a high affi nity of MAP to enteric glial cells and we analyzed the expression of MAP sigma factors under different conditions of growth.
CONCLUSION: The fact that Map showed a high affinity to the glial cells raises concerns about the complicated etiology of the Crohn’s disease. Elucidation of the mechanisms whereby infl ammation alters enteric neural control of gut functions may lead to novel treatments for Crohn’s disease.

Item Type:Article
ID Code:2856
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycobacterium avium subspecies paratuberculosis, enteric glial cells, inflammatory bowel diseases, Crohn’s disease, sigma factors expression
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:W J G Press
ISSN:1007-9327
Deposited On:28 Aug 2009 11:13

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