Sechi, Leonardo Antonio and Rühl, Anne and Ahmed, Niyaz and Usai, Donatella and Paccagnini, Daniela and Felis, Giovanna E. and Zanetti, Stefania Anna Lucia (2007) Mycobacterium aviumsubspecies paratuberculosis infects and multiplies in enteric glial cells. World Journal of Gastroenterology, Vol. 13 (43), p. 5731-5735. ISSN 1007-9327. Article.
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AIM: To establish the role of enteric glial cells during
infection with Mycobacterium avium subspecies
paratuberculosis (MAP) in Crohn’s disease.
METHODS: In order to establish the role of enteric
glial cells during infection with M. avium subspecies
paratuberculosis (MAP) in Crohn’s disease, Map adhesion
experiments on enteric glial cells were performed as
well as expression analysis of Map sigma factors during
RESULTS: In this study, for the fi rst time, we found a
high affi nity of MAP to enteric glial cells and we analyzed
the expression of MAP sigma factors under different
conditions of growth.
CONCLUSION: The fact that Map showed a high affinity
to the glial cells raises concerns about the complicated
etiology of the Crohn’s disease. Elucidation of the
mechanisms whereby infl ammation alters enteric neural
control of gut functions may lead to novel treatments for
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