UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Humoral immune responses of type 1 diabetes patients to Mycobacterium avium subsp. paratuberculosis lend support to the infectious trigger hypothesis

Sechi, Leonardo Antonio and Rosu, Valentina and Pacifico, Adolfo and Fadda, Giovanni and Ahmed, Niyaz and Zanetti, Stefania Anna Lucia (2008) Humoral immune responses of type 1 diabetes patients to Mycobacterium avium subsp. paratuberculosis lend support to the infectious trigger hypothesis. Clinical and Vaccine Immunology, Vol. 15 (2), p. 320-326. eISSN 1556-679X. Article.

Full text not available from this repository.

DOI: 10.1128/CVI.00381-07

Abstract

Mycobacterium avium subsp. paratuberculosis is a zoonotic pathogen whose association with Crohn's disease in humans is under scrutiny. The objective of this work was to investigate its association with other chronic diseases such as type 1 diabetes mellitus (T1DM), where the involvement of a persistent pathogen such as M. avium subsp. paratuberculosis could be the trigger. For this purpose, 59 diabetic patients and 59 healthy controls were investigated for the presence of antibodies against two recombinant proteins of M. avium subsp. paratuberculosis and the whole-cell lysate. Extremely significant humoral immune responses to recombinant heparin binding hemagglutinin and glycosyl transferase proteins and the whole-cell lysates of M. avium subsp. paratuberculosis bacilli were observed in T1DM patients and compared to those of healthy controls. Finding evidence of M. avium subsp. paratuberculosis involvement in T1DM is perhaps a novel finding that might serve as a foundation stone in establishing an infectious etiology for T1DM.

Item Type:Article
ID Code:2853
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycobacterium avium subsp. paratuberculosis, Chron's disease, diabetes mellitus
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:American Society for Microbiology
eISSN:1556-679X
Deposited On:28 Aug 2009 08:50

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page