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Heparin binding haemagglutin as potential diagnostic marker of Mycobacterium bovis

Molicotti, Paola and Bua, Alessandra and Ortu, Silvia and Ladu, Maura C. and Delogu, Giovanni and Mura, Antonio and Sechi, Leonardo Antonio and Fadda, Giovanni and Zanetti, Stefania Anna Lucia (2008) Heparin binding haemagglutin as potential diagnostic marker of Mycobacterium bovis. New Microbiologica, Vol. 31 (3), p. 423-427. ISSN 1121-7138. Article.

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Abstract

In this study, we characterized the humoral responses in cattle of Sardinia. The animals were divided into three groups: 1) 28 cattle infected with Mycobacterium bovis; 2) 48 cattle from herds in which foci of infection was notified; 3) 50 cattle from herds that were TB-free. Levels of IgG antibody were measured against the following antigens of M. tuberculosis: Heparin-Binding-Haemagglutin (HBHA), Ag85B, PPE44, and PE_PGRS33 to investigate their potential to diagnose TB in animals. Our results indicated that HBHA is a potential candidate for the development of a serological assay for rapid diagnosis of cattle infected with M. bovis.

Item Type:Article
ID Code:2848
Status:Published
Refereed:Yes
Uncontrolled Keywords:HBHA, Mycobacterium bovis, humoral response, bovine tuberculosis
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Edizioni internazionali
ISSN:1121-7138
Deposited On:27 Aug 2009 10:38

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