Sechi, Leonardo Antonio and Zanetti, Stefania Anna Lucia and Duprè, Ilaria and Aceti, Antonio and Sanguinetti, Maurizio and Fadda, Giovanni (1998) Genotypic changes in DNA fingerprinting patterns of Mycobacterium tuberculosis strains from HIV-positive persons in Sardinia. AIDS, Vol. 12 (15), p. 2084-2086. eISSN 1473-5571. Article.
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Amongst infectious diseases, tuberculosis is still the major killer in the world. In some developing countries tuberculosis infection has reached epidemic proportions and is increasing worldwide. This rapid growth is thought to be correlated in part to the movement of people from developing countries, where tuberculosis largely occurs, to industrialized countries. It is also due in part to AIDS, as Mycobacterium tuberculosis infection appears to be one of the first indications of a loss of immune system function, and those infected are susceptible to a number of opportunistic infections, including infections by other mycobacteria, and finally because the expectation of life is increased. In the present study, we applied a computer-assisted method to analyse DNA fingerprints and construct dendrograms of M. tuberculosis strains isolated from HIV-positive patients.
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