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Impaired decision-making in opiate-dependent subjects: effect of pharmacological therapies

Pirastu, Roberto and Fais, Rossana and Messina, Monica and Bini, V. and Spiga, Saturnino and Falconieri, Danilo and Diana, Marco (2006) Impaired decision-making in opiate-dependent subjects: effect of pharmacological therapies. Drug and Alcohol Dependence, Vol. 83 (2), p. 163-168. ISSN 0376-8716. Article.

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DOI: 10.1016/j.drugalcdep.2005.11.008


Cognitive dysfunction is a major feature of drug addiction. In the present paper, we compared the decision-making ability using the Iowa gambling task of methadone- and buprenorphine-maintained individuals to non opiate-dependent drug-free controls. Buprenorphine-maintained individuals performed better than methadone-maintained individuals, and not differently than non opiate-dependent controls. In addition, methadone-maintained individuals had more perseverative errors on the Wisconsin card sorting task (WCST) as compared with non opiate-dependent drug-free controls whereas buprenorphine-maintained individuals had intermediate scores. Scores on Weschler adult intelligence scale (WAIS-R) were similar for methadone- and buprenorphine-maintained individuals whereas drug-free controls had significantly higher scores. In addition, both opiate-dependent groups performed more poorly than drug-free controls on the Benton visual retention test (BVRT). The results suggest that buprenorphine in contrast to methadone improves decision-making, and thus may be more effective in rehabilitation programs of opiate-dependent subjects and this improvement may be related to its distinct pharmacological action as a k antagonist.

Item Type:Article
ID Code:2817
Uncontrolled Keywords:Methadone, buprenorphine, cognitive functions, gambling task, decision-making, humans
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Elsevier Ireland
Deposited On:25 Aug 2009 11:50

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