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Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Carlton, Jane M. and Hirt, Robert P. and Silva, Joana C. and Delcher, Arthur L. and Schatz, Michael and Zhao, Qi and Wortman, Jennifer R. and Bidwell, Shelby L. and Alsmark, U. Cecilia M. and Besteiro, Sébastien and Sicheritz Pontén, Thomas and Noel, Christophe J. and Dacks, Joel B. and Foster, Peter G. and Simillion, Cedric and Peer, Yves, van de and Miranda-Saavedra, Diego and Barton, Geoffrey J. and Westrop, Gareth D. and Müller, Sylke and Dessì, Daniele and Fiori, Pier Luigi and Ren, Qinghu and Paulsen, Ian and Zhang, Hanbang and Bastida-Corcuera, Felix D. and Simoes-Barbosa, Augusto and Brown, Mark T. and Hayes, Richard D. and Mukherjee, Mandira and Okumura, Cheryl Y. and Schneider, Rachel and Smith, Alias J. and Vanacova, Stepanka and Villalvazo, Maria and Haas, Brian J. and Pertea, Mihaela and Feldblyum, Tamara V. and Utterback, Terry R. and Shu, Chung-Li and Osoegawa, Kazutoyo and de Jong, Pieter J. and Hrdy, Ivan and Horvathova, Lenka and Zubacova, Zuzana and Dolezal, Pavel and Malik, Shehre-Banoo and Logsdon, John M., Jr and Henze, Katrin and Gupta, Arti and Wang, Ching C. and Dunne, Rebecca L. and Upcroft, Jacqueline A. and Upcroft, Peter and White, Owen and Salzberg, Steven L. and Tang, Petrus and Chiu, Cheng-Hsun and Lee, Ying-Shiung and Embley, T. Martin and Coombs, Graham H. and Mottram, Jeremy C. and Tachezy, Jan and Fraser-Liggett, Claire M. and Johnson, Patricia J. (2007) Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science, Vol. 315 (5809), p. 207-212. eISSN 1095-9203. Article.

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DOI: 10.1126/science.1132894

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Abstract

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ~160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

Item Type:Article
ID Code:2809
Status:Published
Refereed:Yes
Uncontrolled Keywords:Trichomonas vaginalis, lateral gene transfer, pathogenesis
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:American Association for the Advancement of Science
eISSN:1095-9203
Deposited On:24 Aug 2009 13:32

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