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Genetically engineered stem cell therapy for tissue regeneration

Alessandri, Giulio and Emanueli, Costanza and Madeddu, Paolo Roberto (2004) Genetically engineered stem cell therapy for tissue regeneration. Annals of the New York Academy of Sciences, Vol. 1015 (1), p. 271-284. eISSN 1749-6632. Article.

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DOI: 10.1196/annals.1302.023


Therapeutic angiogenesis/vasculogenesis represents a new approach to treat patients with ischemic disease not curable with conventional treatment. This review focuses on the rationale and preliminary results of combining stem cell and gene therapy for regenerative medicine. Under disease conditions, impaired neovascularization results from diminished vascular growth factor production and primary dysfunction of endothelial cells and their progenitors. Advances in our ability to genetically manipulate cells ex vivo has provided the technological platform to implement stem cell biology and circumvent the potential hazard of direct gene transfer. Ex vivo engineered endothelial progenitor cells have been used for the treatment of peripheral limb ischemia. The approach eliminates the drawback of immune response against viral vectors and makes feasible repeating the therapeutic procedure in case of injury recurrence. The strategy of using stem cells as vectors for curative agents proved to be of value for the treatment of pulmonary hypertension and thrombosis. Transplantation of neural stem cells genetically modified to secrete nerve growth factor was able to ameliorate the death of striatal projection neurons caused by transient focal ischemia in the adult rat. By a similar approach, engineered neural stem cells might be used for treating neurodegenerative disorders. Therefore, genetic manipulation of stem cells opens new avenues for regenerative medicine.

Item Type:Article
ID Code:2707
Uncontrolled Keywords:Stem cells, gene therapy, cell engineering, angiogenesis, vasculogenesis
Subjects:Area 06 - Scienze mediche > MED/11 Malattie dell'apparato cardiovascolare
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
002 Altri enti e centri di ricerca del Nord Sardegna > POLARIS, Parco scientifico e tecnologico della Sardegna, Alghero
002 Altri enti e centri di ricerca del Nord Sardegna > National laboratory of the national institute of biostructures and biosystems, Osilo
Publisher:Blackwell / Wiley
Additional Information:Paper presented at the Workshop on Cardiac engineering: from genes and cells to structure and function, Erice, Italy, September 20-24, 2003.
Deposited On:18 Aug 2009 10:08

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