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Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians

Scola, Letizia and Lio, Domenico and Crivello, Antonio and Candore, Giuseppina and Forte, Giusi Irma and Colonna-Romano, Giuseppina and Pes, Giovanni Mario and Carru, Ciriaco and Ferrucci, Luigi and Deiana, Luca and Baggio, Giovannella and Franceschi, Claudio and Caruso, Calogero (2006) Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians. Rejuvenation Research, Vol. 9 (1), p. 157-160. eISSN 1557-8577. Article.

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DOI: 10.1089/rej.2006.9.157

Abstract

Human leukocyte antigen (HLA) alleles, regulating type and intensity of the immune response, might influence life expectancy. In previous case-control studies the authors have demonstrated that both HLA-DR and -DQ alleles are not associated with longevity in the Sardinian population. On the other hand, association studies are subjected (as part of the homogeneity of the population in terms of geographic origin) to a number of possible confounding factors. Therefore, the authors typed the HLA-DQA1 and HLA-DQB1 alleles in 24 sibs (age range 85 to 97) of 17 centenarians by PCR-SSP. Sib pair analysis showed nonsignificant differences between the observed and expected percentage of DQA or DQB1 allele sharing. Therefore, these data strengthen the view that class II HLA genes have a marginal effect, if any, on the complex longevity trait.

Item Type:Article
ID Code:2650
Status:Published
Refereed:Yes
Uncontrolled Keywords:Centenarians, HLA-DQA1, HLA-DQB1, Immune response, Longevity, Sardinia
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Mary Ann Liebert
eISSN:1557-8577
Additional Information:Pubblicato anche in Experimental Gerontology 2008, Vol. 43, No 2, pp. 114-118
Deposited On:18 Aug 2009 10:08

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